|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:RAF_proto-oncogene_serine/threonine-protein_kinase
gptkb:RAF1
|
|
gptkbp:discoveredBy
|
H. Rapp et al.
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:domain
|
gptkb:CR1_domain
gptkb:CR2_domain
gptkb:CR3_domain
regulatory domain
protein kinase domain
|
|
gptkbp:EC_number
|
2.7.11.1
|
|
gptkbp:encodedBy
|
gptkb:RAF1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5894
|
|
gptkbp:function
|
signal transduction
serine/threonine kinase activity
|
|
gptkbp:HGNC_ID
|
9829
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
C-Raf protein
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:Bcl-2
gptkb:MEK1
gptkb:MEK2
gptkb:PP5
gptkb:RAS_protein
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
cell differentiation
cell proliferation
apoptosis regulation
|
|
gptkbp:length
|
648 amino acids
|
|
gptkbp:locatedOnChromosome
|
3p25
|
|
gptkbp:molecularWeight
|
approximately 74 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Noonan_syndrome
leukemia
melanoma
|
|
gptkbp:OMIM
|
164760
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:3OMV
gptkb:4G0N
|
|
gptkbp:phosphorylates
|
Ser259
Ser338
Ser621
Tyr341
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:RefSeq
|
NP_002867.1
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P04049
|
|
gptkbp:bfsParent
|
gptkb:B-Raf_protein
|
|
gptkbp:bfsLayer
|
6
|