|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:RAF1
|
|
gptkbp:biologicalProcess
|
signal transduction
MAPK cascade
|
|
gptkbp:discoveredBy
|
Julian Downward
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:encodedBy
|
gptkb:RAF1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5894
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:family
|
gptkb:RAF_kinase_family
|
|
gptkbp:function
|
protein kinase activity
serine/threonine-protein kinase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
C-RAF protein
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:MEK1
gptkb:MEK2
gptkb:B-RAF_protein
gptkb:PP5
gptkb:RAS_protein
gptkb:HSP90
gptkb:CDC37
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
3p25
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:cytoplasm
gptkb:plasma_membrane
mitochondrion
|
|
gptkbp:molecularWeight
|
73 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Raf1
|
|
gptkbp:PDB
|
gptkb:3OMV
|
|
gptkbp:phosphorylates
|
Ser259
Ser338
Ser621
Tyr341
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:structure
|
contains three conserved regions (CR1, CR2, CR3)
|
|
gptkbp:subunit
|
homodimer
monomer
heterodimer with B-RAF
|
|
gptkbp:target
|
gptkb:dabrafenib
gptkb:sorafenib
gptkb:vemurafenib
gptkb:regorafenib
raf inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P04049
|
|
gptkbp:bfsParent
|
gptkb:A-RAF_protein
|
|
gptkbp:bfsLayer
|
7
|