|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:BRAF
gptkb:proto-oncogene_B-Raf
|
|
gptkbp:discoveredBy
|
Marais et al.
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodedBy
|
gptkb:BRAF_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
B-RAF protein
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:7q34
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~84 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
melanoma
V600E
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
MAP2K1 (MEK1)
MAP2K2 (MEK2)
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:structure
|
contains Ras-binding domain
contains protein kinase domain
contains cysteine-rich domain
|
|
gptkbp:target
|
gptkb:encorafenib
gptkb:dabrafenib
gptkb:vemurafenib
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:A-RAF_protein
|
|
gptkbp:bfsLayer
|
7
|