|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:class
|
gptkb:Selective_serotonin_reuptake_inhibitors
gptkb:Serotonin-norepinephrine_reuptake_inhibitors
Atypical antidepressants
Monoamine oxidase inhibitors
Tricyclic antidepressants
|
|
gptkbp:contraindication
|
Allergy to active ingredient
Bipolar disorder (without mood stabilizer)
|
|
gptkbp:discoveredBy
|
gptkb:Roland_Kuhn_(imipramine)
|
|
gptkbp:excretion
|
gptkb:Kidneys
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Antidepressants
|
|
gptkbp:introducedIn
|
1950s
|
|
gptkbp:legalStatus
|
Prescription drug
|
|
gptkbp:mechanismOfAction
|
Increase neurotransmitter levels
Inhibit reuptake of dopamine
Inhibit reuptake of norepinephrine
Inhibit reuptake of serotonin
|
|
gptkbp:metabolism
|
Liver
|
|
gptkbp:notableExample
|
gptkb:Agomelatine
gptkb:Amitriptyline
gptkb:Amoxapine
gptkb:Bupropion
gptkb:Citalopram
gptkb:Clomipramine
gptkb:Desvenlafaxine
gptkb:Dosulepin
gptkb:Doxepin
gptkb:Duloxetine
gptkb:Escitalopram
gptkb:Esketamine
gptkb:Fluoxetine
gptkb:Imipramine
gptkb:Isocarboxazid
gptkb:Ketamine_(off-label)
gptkb:Levomepromazine
gptkb:Lofepramine
gptkb:Maprotiline
gptkb:Melitracen
gptkb:Mianserin
gptkb:Milnacipran
gptkb:Mirtazapine
gptkb:Moclobemide
gptkb:Nefazodone
gptkb:Nortriptyline
gptkb:Opipramol
gptkb:Paroxetine
gptkb:Phenelzine
gptkb:Pirlindole
gptkb:Protriptyline
gptkb:Quetiapine_(off-label)
gptkb:Reboxetine
gptkb:S-Adenosyl_methionine_(SAMe)
gptkb:Selegiline
gptkb:Sertraline
gptkb:Setiptiline
gptkb:St_John's_Wort_(herbal)
gptkb:Tianeptine
gptkb:Tranylcypromine
gptkb:Trazodone
gptkb:Trimipramine
gptkb:Venlafaxine
gptkb:Vilazodone
gptkb:Vortioxetine
|
|
gptkbp:pregnancyCategory
|
Varies by drug
|
|
gptkbp:prescribes
|
gptkb:Primary_care_physicians
gptkb:Psychiatrists
|
|
gptkbp:regulates
|
Prescription only
|
|
gptkbp:relatedTo
|
gptkb:psychotherapy
Anxiolytics
Antipsychotics
Mood stabilizers
Stimulants
|
|
gptkbp:riskFactor
|
gptkb:Serotonin_syndrome
Suicidal thoughts (especially in young people)
Withdrawal symptoms
|
|
gptkbp:routeOfAdministration
|
gptkb:Oral
Intravenous
Transdermal
|
|
gptkbp:sideEffect
|
gptkb:Nausea
gptkb:Insomnia
Weight gain
Dizziness
Constipation
Agitation
Drowsiness
Dry mouth
Increased sweating
Sexual dysfunction
|
|
gptkbp:usedFor
|
gptkb:Chronic_pain
Depression
Anxiety disorders
Obsessive-compulsive disorder
Post-traumatic stress disorder
Panic disorder
Social anxiety disorder
Eating disorders
Premenstrual dysphoric disorder
|
|
gptkbp:WHOATCCode
|
N06A
|
|
gptkbp:bfsParent
|
gptkb:Insomnia
|
|
gptkbp:bfsLayer
|
5
|