|
gptkbp:instanceOf
|
gptkb:drug
antidepressant
|
|
gptkbp:approvedBy
|
1963
|
|
gptkbp:ATCCode
|
N06AA10
|
|
gptkbp:brand
|
gptkb:Aventyl
gptkb:Pamelor
|
|
gptkbp:CASNumber
|
72-69-5
|
|
gptkbp:chemicalFormula
|
C19H21N
|
|
gptkbp:contraindication
|
severe liver disease
recent myocardial infarction
concurrent MAOI use
|
|
gptkbp:discoveredBy
|
gptkb:Geigy
|
|
gptkbp:drugClass
|
antidepressant
|
|
gptkbp:eliminationHalfLife
|
18–44 hours
|
|
gptkbp:excretion
|
urine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Nortriptyline
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
norepinephrine reuptake inhibitor
serotonin reuptake inhibitor (weak)
|
|
gptkbp:MedlinePlusID
|
a682620
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
263.38 g/mol
|
|
gptkbp:parent
|
gptkb:amitriptyline
|
|
gptkbp:pregnancyCategory
|
C
C (US)
|
|
gptkbp:proteinBinding
|
93%
|
|
gptkbp:PubChem_CID
|
4543
CHEMBL1407
DB00540
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:arrhythmia
gptkb:orthostatic_hypotension
constipation
blurred vision
weight gain
drowsiness
dry mouth
urinary retention
sexual dysfunction
|
|
gptkbp:synonym
|
gptkb:Nortriptylinum
gptkb:desmethylamitriptyline
|
|
gptkbp:UNII
|
BL03SY4LXB
|
|
gptkbp:usedFor
|
gptkb:major_depressive_disorder
peripheral neuropathy
chronic pain
anxiety disorders
migraine prevention
nocturnal enuresis
|
|
gptkbp:bfsParent
|
gptkb:Antidepressants
|
|
gptkbp:bfsLayer
|
6
|