|
gptkbp:instanceOf
|
gptkb:drug
antidepressant
|
|
gptkbp:approvalYear
|
1961
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
N06AA09
|
|
gptkbp:brand
|
gptkb:Amitrol
gptkb:Elavil
gptkb:Endep
gptkb:Laroxyl
gptkb:Tryptanol
|
|
gptkbp:CASNumber
|
50-48-6
|
|
gptkbp:chemicalFormula
|
C20H23N
|
|
gptkbp:contraindication
|
severe liver disease
recent myocardial infarction
concurrent MAOI use
|
|
gptkbp:discoveredBy
|
gptkb:Merck
|
|
gptkbp:discoveredIn
|
1960
|
|
gptkbp:drugInteraction
|
gptkb:beer
gptkb:MAO_inhibitors
gptkb:SSRIs
anticholinergics
antihypertensives
|
|
gptkbp:eliminationHalfLife
|
10–50 hours
|
|
gptkbp:excretion
|
urine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Amitriptyline
|
|
gptkbp:KEGGID
|
D07441
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits reuptake of serotonin and norepinephrine
antagonist at histamine H1 receptors
antagonist at muscarinic acetylcholine receptors
antagonist at alpha-1 adrenergic receptors
|
|
gptkbp:MedlinePlusID
|
a682388
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
277.403 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
96%
|
|
gptkbp:PubChem_CID
|
2160
CHEMBL26
DB00321
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:arrhythmia
gptkb:orthostatic_hypotension
constipation
blurred vision
weight gain
drowsiness
dry mouth
urinary retention
sexual dysfunction
|
|
gptkbp:UNII
|
2ZCN55GSZ1
|
|
gptkbp:usedFor
|
gptkb:major_depressive_disorder
peripheral neuropathy
chronic pain
insomnia
anxiety disorders
fibromyalgia
irritable bowel syndrome
migraine prevention
|
|
gptkbp:bfsParent
|
gptkb:Antidepressants
|
|
gptkbp:bfsLayer
|
6
|