|
gptkbp:instanceOf
|
antidepressant
|
|
gptkbp:ATCCode
|
N06AA06
|
|
gptkbp:CASNumber
|
739-71-9
|
|
gptkbp:category
|
anticholinergics
antihistamines
antidepressants
CYP2D6 substrates
tricyclic compounds
|
|
gptkbp:chemicalFormula
|
C20H26N2O
|
|
gptkbp:contraindication
|
gptkb:arrhythmias
recent myocardial infarction
mania
|
|
gptkbp:discoveredBy
|
gptkb:Ciba-Geigy
|
|
gptkbp:drugClass
|
antidepressant
|
|
gptkbp:eliminationHalfLife
|
12–24 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:has_metabolite
|
gptkb:2-hydroxytrimipramine
gptkb:desmethyltrimipramine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Trimipramine
|
|
gptkbp:introduced
|
1961
|
|
gptkbp:IUPACName
|
3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
antihistamine
norepinephrine reuptake inhibitor
anticholinergic
alpha-adrenergic antagonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
310.44 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
95%
|
|
gptkbp:PubChem_CID
|
5377
5576
CHEMBL1201272
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:orthostatic_hypotension
constipation
blurred vision
weight gain
drowsiness
dry mouth
urinary retention
|
|
gptkbp:synonym
|
gptkb:Surmontil
|
|
gptkbp:UNII
|
0ZB1SR0QVK
|
|
gptkbp:usedFor
|
gptkb:depression
insomnia
anxiety disorders
|
|
gptkbp:bfsParent
|
gptkb:Antidepressants
|
|
gptkbp:bfsLayer
|
6
|