|
gptkbp:instanceOf
|
gptkb:drug
antidepressant
smoking cessation aid
|
|
gptkbp:approvalYear
|
1985
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
N06AX12
|
|
gptkbp:brand
|
gptkb:Wellbutrin
gptkb:Zyban
|
|
gptkbp:CASNumber
|
34841-39-9
|
|
gptkbp:cause
|
anxiety
hypertension
weight loss
|
|
gptkbp:chemicalFormula
|
C13H18ClNO
|
|
gptkbp:compatibleWith
|
gptkb:MAOI
benzodiazepine
controlled substance
opioid
antidepressant
SSRI
|
|
gptkbp:contraindication
|
eating disorders
seizure disorder
|
|
gptkbp:discoveredBy
|
gptkb:Burroughs_Wellcome
|
|
gptkbp:discoveredIn
|
1969
|
|
gptkbp:drugClass
|
aminoketone
|
|
gptkbp:eliminationHalfLife
|
21 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:hasBoxedWarning
|
suicidality in children, adolescents, and young adults
|
|
gptkbp:hasEnantiomer
|
gptkb:(R)-bupropion
gptkb:(S)-bupropion
|
|
gptkbp:hasGenericVersion
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Bupropion
|
|
gptkbp:interactsWith
|
gptkb:beer
gptkb:levodopa
gptkb:phenytoin
gptkb:MAO_inhibitors
gptkb:ritonavir
gptkb:carbamazepine
cimetidine
antipsychotics
anticonvulsants
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
gptkb:United_States
|
|
gptkbp:mechanismOfAction
|
norepinephrine reuptake inhibitor
|
|
gptkbp:metabolism
|
gptkb:erythrohydrobupropion
gptkb:hydroxybupropion
gptkb:threohydrobupropion
liver
|
|
gptkbp:patentExpired
|
2006
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
444
DB01156
|
|
gptkbp:riskFactor
|
gptkb:angle-closure_glaucoma
hypertension
allergic reactions
neuropsychiatric symptoms
lowered seizure threshold
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
headache
seizures
insomnia
dry mouth
|
|
gptkbp:UNII
|
01ZG3TPX31
|
|
gptkbp:usedFor
|
gptkb:depression
gptkb:major_depressive_disorder
smoking cessation
|
|
gptkbp:usedOffLabelFor
|
gptkb:hypoactive_sexual_desire_disorder
bipolar disorder
obesity
ADHD
peripheral neuropathy
anxiety disorders
fibromyalgia
sexual dysfunction
|
|
gptkbp:bfsParent
|
gptkb:Antidepressants
|
|
gptkbp:bfsLayer
|
6
|