Selective serotonin reuptake inhibitors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	class of antidepressant medications
gptkbp:abbreviation	gptkb:SSRIs
gptkbp:approvalYear	1987
gptkbp:approvedBy	gptkb:fluoxetine
gptkbp:ATCCode	N06AB
gptkbp:commonBrandNames	gptkb:Lexapro gptkb:Zoloft gptkb:Celexa gptkb:Luvox gptkb:Paxil gptkb:Prozac
gptkbp:contraindication	concurrent use with MAO inhibitors
gptkbp:discoveredIn	1970s
gptkbp:drugClass	antidepressant serotonergic agent
gptkbp:eliminationHalfLife	varies by drug
gptkbp:example	gptkb:citalopram gptkb:escitalopram gptkb:fluvoxamine gptkb:paroxetine gptkb:sertraline gptkb:fluoxetine
https://www.w3.org/2000/01/rdf-schema#label	Selective serotonin reuptake inhibitors
gptkbp:interactsWith	gptkb:warfarin gptkb:NSAIDs gptkb:triptans other serotonergic drugs
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	inhibit reuptake of serotonin increase serotonin levels in synaptic cleft
gptkbp:metabolism	liver
gptkbp:pregnancyCategory	varies by drug
gptkbp:prescribes	psychiatrists primary care physicians
gptkbp:riskFactor	gptkb:serotonin_syndrome
gptkbp:routeOfAdministration	oral
gptkbp:sideEffect	nausea headache weight gain insomnia dry mouth sexual dysfunction increased risk of suicidal thoughts in young people
gptkbp:usedFor	gptkb:obsessive-compulsive_disorder gptkb:panic_disorder gptkb:post-traumatic_stress_disorder gptkb:major_depressive_disorder gptkb:bulimia_nervosa anxiety disorders
gptkbp:bfsParent	gptkb:Antidepressants
gptkbp:bfsLayer	6