|
gptkbp:instanceOf
|
gptkb:antidepressant
gptkb:drug
|
|
gptkbp:approvedBy
|
1967
|
|
gptkbp:ATCCode
|
N06AA11
|
|
gptkbp:blackBoxWarning
|
increased risk of suicidal thinking in young people
|
|
gptkbp:brand
|
gptkb:Vivactil
|
|
gptkbp:CASNumber
|
438-60-8
|
|
gptkbp:chemicalClass
|
dibenzocycloheptene
|
|
gptkbp:color
|
orange (Vivactil tablet)
|
|
gptkbp:contraindication
|
recent myocardial infarction
hypersensitivity to protriptyline
|
|
gptkbp:developedBy
|
gptkb:Merck_&_Co.
|
|
gptkbp:discontinued
|
2017
|
|
gptkbp:eliminationHalfLife
|
54-92 hours
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:form
|
gptkb:tablet
|
|
gptkbp:has_stereochemistry
|
gptkb:racemic_mixture
|
|
gptkbp:hasMolecularFormula
|
C19H21N
|
|
gptkbp:KEGGID
|
D08441
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits reuptake of norepinephrine and serotonin
|
|
gptkbp:MedlinePlusID
|
a682010
|
|
gptkbp:MeSH_ID
|
D011374
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:pregnancyCategory
|
gptkb:B2
C (US)
|
|
gptkbp:proteinBinding
|
85%
|
|
gptkbp:PubChem_CID
|
4947
CHEMBL1201
DB00344
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:orthostatic_hypotension
constipation
blurred vision
weight gain
drowsiness
dry mouth
urinary retention
|
|
gptkbp:synonym
|
gptkb:Vivactil
|
|
gptkbp:UNII
|
K4IF1Z1Z1Q
|
|
gptkbp:usedFor
|
gptkb:depression
gptkb:attention_deficit_hyperactivity_disorder
narcolepsy
|
|
gptkbp:bfsParent
|
gptkb:Antidepressants
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Protriptyline
|