|
gptkbp:instanceOf
|
antidepressant
|
|
gptkbp:ATCCode
|
gptkb:N06AA16
|
|
gptkbp:availableOn
|
gptkb:Australia
gptkb:India
gptkb:UK
|
|
gptkbp:brand
|
gptkb:Dothep
gptkb:Prothiaden
gptkb:Prothiadene
gptkb:Thaden
|
|
gptkbp:CASNumber
|
gptkb:113-53-1
|
|
gptkbp:contraindication
|
gptkb:arrhythmias
severe liver disease
recent myocardial infarction
mania
|
|
gptkbp:discoveredBy
|
gptkb:Roche
|
|
gptkbp:eliminationHalfLife
|
14-20 hours
|
|
gptkbp:hasMolecularFormula
|
C19H21NS
|
|
gptkbp:hasUNII
|
Q9Y5X4F2G0
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Dosulepin
|
|
gptkbp:introducedIn
|
1960s
|
|
gptkbp:isNotAvailableIn
|
gptkb:Canada
gptkb:Japan
gptkb:United_States
|
|
gptkbp:IUPACName
|
3-(6H-benzo[b][1]benzothiepin-11-ylidene)-N,N-dimethylpropan-1-amine
|
|
gptkbp:KEGGID
|
gptkb:D07841
|
|
gptkbp:legalStatus
|
prescription only (UK)
|
|
gptkbp:mechanismOfAction
|
antihistamine
norepinephrine reuptake inhibitor
anticholinergic
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:notRecommendedFor
|
children
elderly (caution)
|
|
gptkbp:overdoseSymptoms
|
high
|
|
gptkbp:pregnancyCategory
|
gptkb:C_(Australia)
|
|
gptkbp:PubChem_CID
|
DB00564
3107
CHEMBL1407
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
constipation
blurred vision
weight gain
drowsiness
dry mouth
|
|
gptkbp:synonym
|
gptkb:dothiepin
|
|
gptkbp:usedFor
|
gptkb:depression
anxiety
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
no
|
|
gptkbp:bfsParent
|
gptkb:Antidepressants
|
|
gptkbp:bfsLayer
|
6
|