|
gptkbp:instanceOf
|
antidepressant
selective serotonin reuptake inhibitor
|
|
gptkbp:approvalYear
|
1991
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:N06AB06
|
|
gptkbp:bioavailability
|
44%
|
|
gptkbp:brand
|
gptkb:Lustral
gptkb:Zoloft
|
|
gptkbp:CASNumber
|
gptkb:79617-96-2
|
|
gptkbp:category
|
gptkb:World_Health_Organization_essential_medicines
antidepressants
|
|
gptkbp:chemicalFormula
|
C17H17Cl2N
|
|
gptkbp:contraindication
|
concurrent use with MAO inhibitors
allergy to sertraline
|
|
gptkbp:discoveredBy
|
gptkb:Pfizer
|
|
gptkbp:eliminationHalfLife
|
26 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:firstMarketedYear
|
1991
|
|
gptkbp:genericAvailable
|
yes
|
|
gptkbp:hasEnantiomer
|
gptkb:(R)-sertraline
gptkb:(S)-sertraline
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sertraline
|
|
gptkbp:interactsWith
|
gptkb:warfarin
gptkb:MAO_inhibitors
gptkb:NSAIDs
gptkb:pimozide
other serotonergic drugs
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits reuptake of serotonin
|
|
gptkbp:metabolism
|
gptkb:desmethylsertraline
liver
|
|
gptkbp:molecularWeight
|
306.23 g/mol
|
|
gptkbp:patentedYear
|
1970s
|
|
gptkbp:pregnancyCategory
|
C
C (US)
|
|
gptkbp:proteinBinding
|
98%
|
|
gptkbp:PubChem_CID
|
68617
DB01104
|
|
gptkbp:riskOfSerotoninSyndrome
|
yes
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
diarrhea
dizziness
insomnia
dry mouth
sexual dysfunction
|
|
gptkbp:UNII
|
QJ0KD7J8U7
|
|
gptkbp:usedFor
|
gptkb:obsessive-compulsive_disorder
gptkb:panic_disorder
gptkb:post-traumatic_stress_disorder
gptkb:social_anxiety_disorder
gptkb:major_depressive_disorder
premenstrual dysphoric disorder
|
|
gptkbp:bfsParent
|
gptkb:Antidepressants
|
|
gptkbp:bfsLayer
|
6
|