S-Adenosyl methionine (SAMe)

URI: https://gptkb.org/entity/S-Adenosyl_methionine_(SAMe)

GPTKB entity

Statements (55)

Predicate	Object
gptkbp:instanceOf	gptkb:chemical_compound gptkb:coenzyme
gptkbp:alternativeName	gptkb:SAMe gptkb:AdoMet gptkb:SAM
gptkbp:biosynthesized_from	gptkb:ATP methionine
gptkbp:CASNumber	29908-03-0
gptkbp:category	biochemistry dietary supplement amino acid derivative methyl donor
gptkbp:chemicalFormula	C15H22N6O5S
gptkbp:contraindication	gptkb:Parkinson's_disease bipolar disorder
gptkbp:discoveredBy	gptkb:Giulio_Cantoni 1952
gptkbp:enzyme_involved_in_biosynthesis	gptkb:methionine_adenosyltransferase
gptkbp:foundIn	all living cells
https://www.w3.org/2000/01/rdf-schema#label	S-Adenosyl methionine (SAMe)
gptkbp:involves	DNA methylation histone methylation RNA methylation methionine cycle one-carbon metabolism phosphatidylcholine synthesis polyamine biosynthesis
gptkbp:IUPACName	gptkb:S-adenosyl-L-methionine
gptkbp:KEGGID	C00019
gptkbp:meltingPoint	decomposes before melting
gptkbp:MeSH_ID	D012469
gptkbp:metabolism	gptkb:S-adenosylhomocysteine
gptkbp:molecularWeight	398.44 g/mol
gptkbp:PubChem_CID	gptkb:CHEBI:16811 gptkb:DB00118 34755
gptkbp:regulates	dietary supplement in the United States prescription drug in some European countries
gptkbp:relatedTo	aminopropylation transmethylation transsulfuration
gptkbp:role	cofactor in methylation reactions methyl group donor precursor in biosynthesis of polyamines
gptkbp:sideEffect	anxiety insomnia gastrointestinal upset
gptkbp:UNII	Q1JQF9J1Y5
gptkbp:usedFor	gptkb:depression gptkb:liver_disease dietary supplement osteoarthritis
gptkbp:water_solubility	soluble
gptkbp:bfsParent	gptkb:Antidepressants
gptkbp:bfsLayer	6