|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:Siglec-3
gptkb:gp67
|
|
gptkbp:associatedWith
|
gptkb:acute_myeloid_leukemia
|
|
gptkbp:biologicalProcess
|
immune response
negative regulation of cell activation
|
|
gptkbp:cellSurfaceMarker
|
yes
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:domain
|
IgV-like domain
IgC2-like domain
|
|
gptkbp:encodedBy
|
gptkb:CD33_gene
|
|
gptkbp:Entrez_Gene_ID
|
945
|
|
gptkbp:expressedIn
|
myeloid cells
monocytes
granulocytes
|
|
gptkbp:function
|
inhibition of immune cell activation
cell-cell interaction
regulation of innate immunity
|
|
gptkbp:HGNC_ID
|
1659
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD33
|
|
gptkbp:inhibitedBy
|
phagocytosis
|
|
gptkbp:involvedIn
|
Alzheimer's disease risk
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
gptkb:19q13.41
|
|
gptkbp:memberOf
|
gptkb:sialic_acid-binding_immunoglobulin-like_lectins_(Siglecs)
|
|
gptkbp:molecularWeight
|
40 kDa
|
|
gptkbp:motif
|
ITIM (immunoreceptor tyrosine-based inhibitory motif)
|
|
gptkbp:OMIM
|
159590
|
|
gptkbp:orthologInMouse
|
Cd33
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:target
|
gptkb:gemtuzumab_ozogamicin
|
|
gptkbp:UniProtID
|
P20138
|
|
gptkbp:bfsParent
|
gptkb:acute_promyelocytic_leukemia
|
|
gptkbp:bfsLayer
|
6
|