|
gptkbp:instanceOf
|
protein fragment
|
|
gptkbp:accumulatesIn
|
extracellular space
|
|
gptkbp:aggregatesInto
|
plaques
|
|
gptkbp:alsoKnownAs
|
gptkb:Aβ
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
|
|
gptkbp:cleavage
|
gptkb:beta-secretase
gptkb:gamma-secretase
|
|
gptkbp:derivedFrom
|
gptkb:amyloid_precursor_protein
|
|
gptkbp:discoveredBy
|
gptkb:George_Glenner
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:encodedBy
|
gptkb:APP_gene
|
|
gptkbp:firstIsolatedFrom
|
cerebral blood vessels
|
|
gptkbp:form
|
amyloid plaques
|
|
gptkbp:foundIn
|
brain
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
amyloid-beta
|
|
gptkbp:involvedIn
|
inflammation
oxidative stress
synaptic dysfunction
|
|
gptkbp:involves
|
cerebral amyloid angiopathy
neurodegeneration
|
|
gptkbp:length
|
gptkb:Aβ40
gptkb:Aβ42
|
|
gptkbp:measures
|
cerebrospinal fluid analysis
|
|
gptkbp:sequence
|
derived from APP 695, 751, 770 isoforms
|
|
gptkbp:structure
|
peptide
|
|
gptkbp:studiedIn
|
gptkb:transgenic_mouse_models
|
|
gptkbp:target
|
Alzheimer's disease therapies
|
|
gptkbp:toxicForm
|
fibrils
oligomers
|
|
gptkbp:usedAs
|
biomarker for Alzheimer's disease
|
|
gptkbp:bfsParent
|
gptkb:Alzheimer's_disease_pathway
gptkb:clusterin
gptkb:insulin-degrading_enzyme
|
|
gptkbp:bfsLayer
|
7
|