|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:PI3K_pathway
phosphorylation
|
|
gptkbp:alsoKnownAs
|
gptkb:Protein_kinase_B
|
|
gptkbp:discoveredBy
|
gptkb:Dario_Alessi
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:domain
|
gptkb:pleckstrin_homology_domain
serine/threonine kinase domain
|
|
gptkbp:EC_number
|
2.7.11.1
|
|
gptkbp:encodedBy
|
gptkb:AKT1_gene
gptkb:AKT3_gene
gptkb:AKT2_gene
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
regulation of cell survival
regulation of cell growth
regulation of glucose metabolism
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Akt kinase
|
|
gptkbp:inhibitedBy
|
gptkb:PTEN
phosphatases
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
neurodegenerative disease
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:phosphorylates
|
gptkb:GSK-3
gptkb:TSC2
gptkb:BAD
gptkb:p21
gptkb:p27
gptkb:FOXO_transcription_factors
gptkb:MDM2
gptkb:mTOR
|
|
gptkbp:regulates
|
metabolism
protein synthesis
cell cycle
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
cytosol
|
|
gptkbp:target
|
anticancer drugs
small molecule inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P31749
P31751
Q9Y243
|
|
gptkbp:bfsParent
|
gptkb:FOXO_transcription_factors
|
|
gptkbp:bfsLayer
|
6
|