Abelson murine leukemia viral oncogene homolog 1

URI: https://gptkb.org/entity/Abelson_murine_leukemia_viral_oncogene_homolog_1
GPTKB entity
Statements (37)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alternativeName gptkb:ABL_proto-oncogene_1,_non-receptor_tyrosine_kinase
gptkb:c-ABL
gptkbp:associatedWith gptkb:chronic_myeloid_leukemia
leukemia
gptkbp:biologicalProcess apoptosis
cell differentiation
signal transduction
cell division
ATP binding
protein kinase activity
protein binding
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:discoveredBy Herbert Abelson
gptkbp:encodes ABL1 protein
gptkbp:Entrez_Gene_ID 25
ENSG00000097007
gptkbp:function tyrosine kinase activity
gptkbp:HGNC_ID HGNC:76
https://www.w3.org/2000/01/rdf-schema#label Abelson murine leukemia viral oncogene homolog 1
gptkbp:locatedOnChromosome gptkb:chromosome_9
gptkbp:mutationAssociatedWith gptkb:Philadelphia_chromosome
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn v-abl oncogene
gptkbp:PDB 1OPL
gptkbp:symbol gptkb:ABL1
gptkbp:targetOfDrug gptkb:bosutinib
gptkb:dasatinib
gptkb:ponatinib
gptkb:imatinib
gptkb:nilotinib
gptkbp:UniProtID P00519
gptkbp:bfsParent gptkb:ABL1_gene
gptkb:BCR-ABL_fusion_gene
gptkbp:bfsLayer 7