|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
H. Hanafusa
|
|
gptkbp:domain
|
SH2 domain
SH3 domain
DNA-binding domain
tyrosine kinase domain
|
|
gptkbp:EC_number
|
2.7.10.2
|
|
gptkbp:encodedBy
|
gptkb:ABL1_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
cell differentiation
signal transduction
cell division
cell adhesion
stress response
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-ABL
|
|
gptkbp:inhibitedBy
|
gptkb:bosutinib
gptkb:dasatinib
gptkb:ponatinib
gptkb:imatinib
gptkb:nilotinib
|
|
gptkbp:locatedOnChromosome
|
gptkb:9q34
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:chronic_myeloid_leukemia
leukemia
|
|
gptkbp:orthologIn
|
v-ABL
|
|
gptkbp:PDB
|
2FO0
2GQG
2HYY
1OPL
|
|
gptkbp:phosphorylates
|
gptkb:p73
gptkb:RNA_polymerase_II
gptkb:CRK
gptkb:RAD51
gptkb:STAT5
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
myristoylation
|
|
gptkbp:regulates
|
apoptosis
cell cycle
DNA damage response
actin cytoskeleton
|
|
gptkbp:relatedTo
|
gptkb:BCR-ABL_fusion_protein
|
|
gptkbp:UniProtID
|
P00519
|
|
gptkbp:bfsParent
|
gptkb:ABL1_gene
|
|
gptkbp:bfsLayer
|
7
|