ABL proto-oncogene 1, non-receptor tyrosine kinase

URI: https://gptkb.org/entity/ABL_proto-oncogene_1,_non-receptor_tyrosine_kinase
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alternativeName gptkb:c-ABL
v-abl Abelson murine leukemia viral oncogene homolog 1
Abelson tyrosine-protein kinase 1
gptkbp:associatedWith gptkb:chronic_myeloid_leukemia
leukemia
gptkbp:biologicalProcess cell differentiation
signal transduction
cell division
ATP binding
cell adhesion
stress response
protein binding
protein tyrosine kinase activity
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:discoveredBy H. Hanafusa
gptkbp:encodes ABL1 protein
gptkbp:Entrez_Gene_ID 25
ENSG00000097007
gptkbp:expressedIn gptkb:human
gptkb:mouse
gptkbp:function tyrosine kinase activity
gptkbp:HGNC_ID 76
https://www.w3.org/2000/01/rdf-schema#label ABL proto-oncogene 1, non-receptor tyrosine kinase
gptkbp:length 1130 amino acids
gptkbp:locatedOnChromosome gptkb:chromosome_9
gptkbp:mergedInto BCR gene
gptkbp:molecularWeight 122 kDa
gptkbp:mutationAssociatedWith gptkb:Philadelphia_chromosome
gptkbp:OMIM 189980
gptkbp:orthologInMouse Abl1
gptkbp:PDB 1OPL
gptkbp:phosphorylates tyrosine 245
tyrosine 412
gptkbp:proteinFamily tyrosine-protein kinase family
gptkbp:regulates apoptosis
cell migration
actin cytoskeleton
gptkbp:symbol gptkb:ABL1
gptkbp:target gptkb:bosutinib
gptkb:dasatinib
gptkb:ponatinib
gptkb:imatinib
gptkb:nilotinib
gptkbp:UniProtID P00519
gptkbp:bfsParent gptkb:ABL1_gene
gptkbp:bfsLayer 7