|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:Abelson_murine_leukemia_viral_oncogene_homolog_1
gptkb:c-ABL
JTK7
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:chronic_myeloid_leukemia
gptkb:acute_myeloid_leukemia
leukemia
|
|
gptkbp:BCR-ABL_fusion_protein
|
gptkb:Philadelphia_chromosome
|
|
gptkbp:biologicalProcess
|
regulation of cell differentiation
regulation of cell division
tyrosine kinase activity
regulation of cell adhesion
regulation of stress response
|
|
gptkbp:discoveredBy
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gptkb:David_Baltimore
|
|
gptkbp:encodes
|
gptkb:ABL_proto-oncogene_1,_non-receptor_tyrosine_kinase
|
|
gptkbp:Entrez_Gene_ID
|
25
ENSG00000097007
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
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gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:76
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ABL1 gene
|
|
gptkbp:length
|
149 kilobases
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9q34
|
|
gptkbp:mutationAssociatedWith
|
gptkb:BCR-ABL_fusion_protein
|
|
gptkbp:numberOfExons
|
11
|
|
gptkbp:OMIM
|
189980
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
gptkb:p73
gptkb:RNA_polymerase_II
gptkb:CRK
gptkb:RAD51
gptkb:STAT5
gptkb:cortactin
|
|
gptkbp:regulates
|
apoptosis
cell migration
DNA damage response
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
gptkb:bosutinib
gptkb:dasatinib
gptkb:ponatinib
gptkb:imatinib
gptkb:nilotinib
|
|
gptkbp:UniProtID
|
P00519
|
|
gptkbp:bfsParent
|
gptkb:ABL
|
|
gptkbp:bfsLayer
|
6
|