|
gptkbp:instanceOf
|
gptkb:tumor_suppressor
gptkb:gene
|
|
gptkbp:associatedWith
|
gptkb:leukemia
gptkb:chronic_myeloid_leukemia
|
|
gptkbp:cause
|
uncontrolled cell proliferation
constitutive tyrosine kinase activity
|
|
gptkbp:chromosomalTranslocation
|
gptkb:Philadelphia_chromosome
|
|
gptkbp:detects
|
gptkb:FISH
PCR
karyotyping
|
|
gptkbp:diagnosedBy
|
Philadelphia chromosome-positive leukemias
|
|
gptkbp:discoveredIn
|
1973
|
|
gptkbp:encodes
|
gptkb:BCR-ABL_protein
|
|
gptkbp:formedBy
|
BCR gene
ABL gene
|
|
gptkbp:inhibitorResistance
|
T315I mutation
|
|
gptkbp:locatedOn
|
chromosome 22
|
|
gptkbp:namedAfter
|
gptkb:Breakpoint_Cluster_Region
gptkb:Abelson_murine_leukemia_viral_oncogene_homolog_1
|
|
gptkbp:product
|
gptkb:p190_BCR-ABL
gptkb:p210_BCR-ABL
gptkb:p230_BCR-ABL
|
|
gptkbp:result
|
gptkb:t(9;22)(q34;q11)_translocation
|
|
gptkbp:target
|
gptkb:bosutinib
gptkb:dasatinib
gptkb:ponatinib
gptkb:imatinib
gptkb:nilotinib
|
|
gptkbp:bfsParent
|
gptkb:chronic_myelogenous_leukemia
gptkb:chronic_myeloid_leukemia
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BCR-ABL fusion gene
|