Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
tumor suppressor |
| gptkbp:associatedWith |
gptkb:chronic_myeloid_leukemia
leukemia |
| gptkbp:cause |
uncontrolled cell proliferation
constitutive tyrosine kinase activity |
| gptkbp:chromosomalTranslocation |
gptkb:Philadelphia_chromosome
|
| gptkbp:detects |
gptkb:FISH
PCR karyotyping |
| gptkbp:diagnosedBy |
Philadelphia chromosome-positive leukemias
|
| gptkbp:discoveredIn |
1973
|
| gptkbp:encodes |
gptkb:BCR-ABL_protein
|
| gptkbp:formedBy |
BCR gene
ABL gene |
| https://www.w3.org/2000/01/rdf-schema#label |
BCR-ABL fusion gene
|
| gptkbp:inhibitorResistance |
T315I mutation
|
| gptkbp:locatedOn |
chromosome 22
|
| gptkbp:namedAfter |
gptkb:Breakpoint_Cluster_Region
gptkb:Abelson_murine_leukemia_viral_oncogene_homolog_1 |
| gptkbp:product |
gptkb:p190_BCR-ABL
gptkb:p210_BCR-ABL gptkb:p230_BCR-ABL |
| gptkbp:result |
gptkb:t(9;22)(q34;q11)_translocation
|
| gptkbp:target |
gptkb:bosutinib
gptkb:dasatinib gptkb:ponatinib gptkb:imatinib gptkb:nilotinib |
| gptkbp:bfsParent |
gptkb:chronic_myeloid_leukemia
|
| gptkbp:bfsLayer |
6
|