|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:CD246
gptkb:anaplastic_lymphoma_receptor_tyrosine_kinase
|
|
gptkbp:associatedWith
|
gptkb:anaplastic_large_cell_lymphoma
gptkb:neuroblastoma
gptkb:non-small_cell_lung_cancer
|
|
gptkbp:discoveredBy
|
gptkb:Steven_A._Morris
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:ALK_protein
|
|
gptkbp:Entrez_Gene_ID
|
238
|
|
gptkbp:expressedIn
|
gptkb:nervous_system
brain
|
|
gptkbp:fullName
|
gptkb:anaplastic_lymphoma_kinase
|
|
gptkbp:function
|
cell growth regulation
neuronal development
receptor tyrosine kinase activity
|
|
gptkbp:HGNC_ID
|
427
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ALK gene
|
|
gptkbp:length
|
1620 amino acids
26 exons
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
2p23
|
|
gptkbp:mutationAssociatedWith
|
gptkb:gene
gptkb:EML4-ALK_fusion
gptkb:NPM-ALK_fusion
drug resistance
gain-of-function
constitutive kinase activation
oncogenic transformation
|
|
gptkbp:OMIM
|
105590
|
|
gptkbp:orthologInMouse
|
gptkb:Alk_(rat_gene)
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:PI3K-AKT_signaling_pathway
gptkb:MAPK_signaling_pathway
cell proliferation pathway
cell survival pathway
|
|
gptkbp:product
|
cell surface receptor
|
|
gptkbp:proteinFamily
|
gptkb:insulin_receptor_subfamily
extracellular domain
transmembrane domain
tyrosine kinase domain
protein tyrosine kinase family
|
|
gptkbp:symbol
|
gptkb:ALK
|
|
gptkbp:targetOfDrug
|
gptkb:alectinib
gptkb:brigatinib
gptkb:ceritinib
gptkb:crizotinib
gptkb:lorlatinib
|
|
gptkbp:UniProtID
|
gptkb:Q9UM73
|
|
gptkbp:bfsParent
|
gptkb:ALK_tyrosine_kinase_receptor
gptkb:CD246
gptkb:anaplastic_lymphoma_kinase
gptkb:anaplastic_lymphoma_kinase_(ALK)
|
|
gptkbp:bfsLayer
|
7
|