Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:disease
gptkb:bile_duct_cancer gptkb:Oncology gptkb:non-Hodgkin_lymphoma gptkb:pancreatic_cancer ovarian cancer metastatic cancer tumor microenvironment liver cancer cancer stem cells esophageal cancer chemoresistance radiation resistance immune evasion bladder cancer head and neck cancer neuroendocrine tumors thymoma sarcomas germ cell tumors adrenocortical carcinoma prognostic marker biomarker for therapy response carcinoid tumors chordoma malignant pleural effusion peritoneal carcinomatosis targeted therapy resistance cancers with ALK rearrangements immunotherapy resistance |
| gptkbp:breeding_range |
2p23.2
|
| gptkbp:code |
gptkb:anaplastic_lymphoma_kinase_protein
|
| gptkbp:discovered_by |
gptkb:M._D._Anderson_Cancer_Center
|
| gptkbp:diseases |
gptkb:idiopathic_pulmonary_fibrosis
gptkb:neuroblastoma |
| gptkbp:field_of_study |
oncology
|
| gptkbp:function |
cell signaling
|
| gptkbp:genetic_studies |
rearrangement
|
| https://www.w3.org/2000/01/rdf-schema#label |
ALK gene
|
| gptkbp:involved_in |
tumorigenesis
|
| gptkbp:is_expressed_in |
varies by tissue
|
| gptkbp:is_recognized_as |
gptkb:1994
|
| gptkbp:located_in |
chromosome 2
|
| gptkbp:orthologs |
found in multiple species
|
| gptkbp:pathway |
MAPK signaling pathway
Ras signaling pathway neurotrophin signaling pathway PI3 K-Akt signaling pathway |
| gptkbp:seed_dispersal |
protein-coding gene
|
| gptkbp:targets |
gptkb:crizotinib
|
| gptkbp:bfsParent |
gptkb:anaplastic_large_cell_lymphoma,_ALK-positive
|
| gptkbp:bfsLayer |
7
|