Statements (70)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:anaplastic_lymphoma
|
| gptkbp:can_detect |
various cancers
|
| gptkbp:code |
gptkb:ALK_gene
|
| gptkbp:genetic_studies |
can lead to cancer
|
| gptkbp:has_function |
regulating cell growth
|
| gptkbp:has_role |
neurodevelopment
|
| https://www.w3.org/2000/01/rdf-schema#label |
ALK protein
|
| gptkbp:involved_in |
cell signaling
|
| gptkbp:is_associated_with |
therapeutic resistance
chemoresistance immune evasion tumor invasion poor prognosis in cancer tumor microenvironment remodeling tumor-associated macrophages |
| gptkbp:is_expressed_in |
gptkb:Oncology
gptkb:pancreatic_cancer gptkb:neuroblastoma ovarian cancer esophageal cancer small cell lung cancer colon cancer bladder cancer head and neck cancer certain types of lymphoma |
| gptkbp:is_involved_in |
cell cycle regulation
cell differentiation cell proliferation cellular metabolism cellular stress response tumorigenesis cell survival tumor microenvironment angiogenesis cell adhesion cell migration cellular communication immune response modulation neural differentiation metabolic reprogramming cellular signaling networks |
| gptkbp:is_linked_to |
gptkb:Oncology
tumor heterogeneity metastasis tumor progression cancer stem cells drug resistance tumor immune evasion tumor cell plasticity |
| gptkbp:is_part_of |
signal transduction pathways
neural crest development neural signaling pathways neural development pathways neuroblastoma pathogenesis neuroblastoma signaling pathways neurogenic signaling receptor tyrosine kinase family |
| gptkbp:is_related_to |
ALK inhibitors
|
| gptkbp:is_studied_in |
oncology
|
| gptkbp:is_targeted_at |
gptkb:brigatinib
gptkb:entrectinib gptkb:lorlatinib gptkb:alectinib gptkb:ceritinib gptkb:crizotinib treatment regimens |
| gptkbp:targets |
targeted therapy
|
| gptkbp:bfsParent |
gptkb:EML4
|
| gptkbp:bfsLayer |
7
|