anaplastic lymphoma receptor tyrosine kinase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alternativeName	gptkb:CD246 gptkb:NBLST3 ALK receptor
gptkbp:associatedWith	gptkb:anaplastic_large_cell_lymphoma gptkb:neuroblastoma gptkb:non-small_cell_lung_cancer
gptkbp:biologicalProcess	cell proliferation signal transduction ATP binding protein tyrosine kinase activity
gptkbp:cellularComponent	gptkb:plasma_membrane
gptkbp:discoveredBy	gptkb:Steven_A._Morris
gptkbp:discoveredIn	1994
gptkbp:encodedBy	gptkb:ALK_gene
gptkbp:Entrez_Gene_ID	ENSG00000171094
gptkbp:expressedIn	gptkb:nervous_system embryonic tissues
gptkbp:function	cell signaling receptor tyrosine kinase activity
gptkbp:gene	gptkb:ALK
gptkbp:HGNC_ID	427
https://www.w3.org/2000/01/rdf-schema#label	anaplastic lymphoma receptor tyrosine kinase
gptkbp:ligand	gptkb:pleiotrophin midkine
gptkbp:locatedOnChromosome	chromosome 2 2p23
gptkbp:mutationAssociatedWith	gptkb:gene point mutation
gptkbp:OMIM	105590
gptkbp:orthologInMouse	gptkb:Alk
gptkbp:pathway	gptkb:JAK-STAT_signaling_pathway gptkb:MAPK_signaling_pathway gptkb:PI3K-Akt_signaling_pathway
gptkbp:PDB	gptkb:3LCS
gptkbp:proteinFamily	gptkb:insulin_receptor_subfamily extracellular domain transmembrane domain tyrosine kinase domain
gptkbp:targetOfDrug	gptkb:alectinib gptkb:brigatinib gptkb:ceritinib gptkb:crizotinib gptkb:lorlatinib
gptkbp:UniProtID	gptkb:Q9UM73
gptkbp:bfsParent	gptkb:ALK_gene
gptkbp:bfsLayer	8