anaplastic lymphoma kinase

URI: https://gptkb.org/entity/anaplastic_lymphoma_kinase
GPTKB entity
Statements (36)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:CD246
gptkb:ALK
gptkbp:associatedWith gptkb:anaplastic_large_cell_lymphoma
gptkb:neuroblastoma
gptkb:non-small_cell_lung_cancer
gptkbp:biologicalProcess ATP binding
protein tyrosine kinase activity
gptkbp:cellularComponent gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:discoveredBy gptkb:Steven_A._Morris
gptkbp:discoveredIn 1994
gptkbp:EC_number 2.7.10.1
gptkbp:encodedBy gptkb:ALK_gene
gptkbp:Entrez_Gene_ID 238
gptkbp:function gptkb:receptor_tyrosine_kinase
cell growth regulation
gptkbp:gene gptkb:ALK
gptkbp:HGNC_ID 427
https://www.w3.org/2000/01/rdf-schema#label anaplastic lymphoma kinase
gptkbp:locatedOnChromosome chromosome 2
2p23
gptkbp:mutationAssociatedWith gptkb:gene
point mutation
gptkbp:OMIM 105590
gptkbp:PDB gptkb:3LCS
gptkbp:species gptkb:Homo_sapiens
gptkbp:targetOfDrug gptkb:alectinib
gptkb:ceritinib
gptkb:crizotinib
gptkb:lorlatinib
gptkbp:UniProtID gptkb:Q9UM73
gptkbp:bfsParent gptkb:brigatinib
gptkb:ALK
gptkbp:bfsLayer 6