Statements (67)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
fusion protein
|
| gptkbp:associated_with |
disease monitoring
treatment resistance cytokine signaling elevated white blood cell counts increased apoptosis resistance increased proliferation increased risk of transformation poor treatment response |
| gptkbp:associatedWith |
blast crisis
chronic myeloid leukemia |
| gptkbp:causedBy |
uncontrolled cell division
|
| gptkbp:characterizedBy |
tyrosine kinase activity
|
| gptkbp:community_service |
CML diagnosis
|
| gptkbp:established |
tyrosine kinase signaling pathways
|
| gptkbp:has_a_focus_on |
targeted therapy
pharmacogenomics research molecular targeted therapy |
| https://www.w3.org/2000/01/rdf-schema#label |
BCR-ABL fusion protein
|
| gptkbp:influences |
gene expression
|
| gptkbp:involvedIn |
leukemogenesis
|
| gptkbp:is_a |
oncogenic driver
BCR_gene_and_ABL_gene |
| gptkbp:is_a_subject_of |
clinical trials
genetic research |
| gptkbp:is_a_symbol_of |
disease progression
|
| gptkbp:is_aimed_at |
second-generation tyrosine kinase inhibitors
|
| gptkbp:is_characterized_by |
abnormal cell signaling
|
| gptkbp:is_evaluated_by |
CML_patients
|
| gptkbp:is_involved_in |
cell cycle regulation
signal transduction cell signaling pathways tumorigenesis cellular signaling pathways tumor microenvironment interactions metastatic disease therapeutic resistance mechanisms cellular transformation chronic phase CML leukocyte proliferation |
| gptkbp:is_linked_to |
chromosomal abnormalities
clinical outcomes tyrosine kinase activity hematological malignancies clinical outcomes in CML resistance mutations clinical_management_of_CML |
| gptkbp:is_monitored_by |
FISH analysis
|
| gptkbp:is_studied_in |
molecular biology
therapeutic interventions cancer research |
| gptkbp:isActiveIn |
apoptosis
DNA repair mechanisms |
| gptkbp:leads |
drug resistance
|
| gptkbp:linkedTo |
poor prognosis
|
| gptkbp:locatedIn |
gptkb:hematopoietic_stem_cells
gptkb:Philadelphia_chromosome |
| gptkbp:producedBy |
translocation between chromosomes 9 and 22
|
| gptkbp:promotes |
cell survival
|
| gptkbp:targets |
personalized medicine
monoclonal antibodies combination therapies imatinib novel therapeutic agents |
| gptkbp:visitedBy |
bone marrow samples
PCR_methods |
| gptkbp:was_a_result_of |
chromosomal translocation
|