retinoid X receptor (RXR)

URI: https://gptkb.org/entity/retinoid_X_receptor_(RXR)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:nuclear_receptor gptkb:protein
gptkbp:activatedBy	gptkb:9-cis-retinoic_acid
gptkbp:alternativeName	gptkb:NR2B1_(RXRA) gptkb:NR2B2_(RXRB) gptkb:NR2B3_(RXRG)
gptkbp:binds	gptkb:9-cis-retinoic_acid
gptkbp:discoveredIn	1990
gptkbp:Entrez_Gene_ID	gptkb:6256_(RXRA) gptkb:6257_(RXRB) gptkb:6258_(RXRG)
gptkbp:formsHeterodimerWith	gptkb:peroxisome_proliferator-activated_receptor_(PPAR) gptkb:farnesoid_X_receptor_(FXR) gptkb:liver_X_receptor_(LXR) gptkb:retinoic_acid_receptor_(RAR) gptkb:thyroid_hormone_receptor_(TR) gptkb:vitamin_D_receptor_(VDR)
gptkbp:foundIn	humans mammals
gptkbp:function	gptkb:transcription_factor
gptkbp:involvedIn	gptkb:immune_response apoptosis cell differentiation development metabolism
gptkbp:locatedOnChromosome	gptkb:chromosome_1_(RXRG) gptkb:chromosome_6_(RXRB) gptkb:chromosome_9_(RXRA)
gptkbp:product	gptkb:RXR_gene
gptkbp:regulates	gene expression
gptkbp:relatedTo	gptkb:cancer gptkb:diabetes atherosclerosis lipid metabolism neurodegenerative diseases retinoic acid signaling pathway
gptkbp:structure	DNA-binding domain ligand-binding domain
gptkbp:subspecies	gptkb:RXR_alpha gptkb:RXR_beta gptkb:RXR_gamma
gptkbp:symbol	gptkb:RXR
gptkbp:target	gptkb:alitretinoin gptkb:rexinoids gptkb:bexarotene
gptkbp:UniProtID	gptkb:P19793_(RXRA) P28702 (RXRB) P48443 (RXRG)
gptkbp:bfsParent	gptkb:LXR
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	retinoid X receptor (RXR)