|
gptkbp:instanceOf
|
nuclear receptor
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes
atherosclerosis
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:domain
|
DNA-binding domain
ligand-binding domain
activation function-2 (AF-2) domain
|
|
gptkbp:encodedBy
|
gptkb:RXRA
RXRB
RXRG
|
|
gptkbp:formsHeterodimerWith
|
gptkb:RAR
gptkb:VDR
gptkb:LXR
PPAR
FXR
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:fullName
|
Retinoid X receptor
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:hasIsoform
|
RXR-alpha
RXR-beta
RXR-gamma
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RXR
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
development
metabolism
|
|
gptkbp:ligand
|
gptkb:9-cis-retinoic_acid
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:modulatedBy
|
gptkb:9-cis-retinoic_acid
gptkb:rexinoids
gptkb:bexarotene
LG100268
LG101506
|
|
gptkbp:PDB
|
1XDK
1FBY
1LBD
|
|
gptkbp:proteinFamily
|
nuclear receptor superfamily
|
|
gptkbp:regulates
|
cell proliferation
gene expression
lipid metabolism
inflammatory response
glucose homeostasis
|
|
gptkbp:symbol
|
gptkb:RXR
|
|
gptkbp:target
|
pharmaceutical research
|
|
gptkbp:UniProtID
|
P19793 (RXR-alpha)
P28702 (RXR-beta)
P48443 (RXR-gamma)
|
|
gptkbp:bfsParent
|
gptkb:retinoid_X_receptor_(RXR)
|
|
gptkbp:bfsLayer
|
7
|