Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
nuclear receptor |
| gptkbp:activatedBy |
bile acids
|
| gptkbp:alternativeName |
NR1H4
bile acid receptor |
| gptkbp:discoveredBy |
1995
|
| gptkbp:encodedBy |
NR1H4 gene
|
| gptkbp:expressedIn |
gptkb:adrenal_gland
gptkb:kidney liver intestine |
| gptkbp:formsHeterodimerWith |
gptkb:retinoid_X_receptor_(RXR)
|
| gptkbp:foundIn |
gptkb:human
gptkb:mouse right |
| gptkbp:function |
regulates glucose metabolism
regulates bile acid homeostasis regulates lipid metabolism |
| gptkbp:gene |
NR1H4
|
| gptkbp:HGNC_ID |
7961
|
| https://www.w3.org/2000/01/rdf-schema#label |
farnesoid X receptor (FXR)
|
| gptkbp:involves |
gptkb:metabolic_syndrome
atherosclerosis cholestasis insulin sensitivity liver regeneration nonalcoholic fatty liver disease gallstone formation |
| gptkbp:locatedOnChromosome |
chromosome 12q23.1
|
| gptkbp:member |
nuclear receptor subfamily 1 group H member 4
|
| gptkbp:OMIM |
603826
|
| gptkbp:PDB |
1OSH
|
| gptkbp:regulates |
gptkb:apolipoprotein_C-II
gptkb:CYP7A1_gene inflammation cholesterol metabolism triglyceride levels apolipoprotein C-III bile salt export pump (BSEP) fibroblast growth factor 19 (FGF19) intestinal absorption of nutrients phospholipid transfer protein small heterodimer partner (SHP) |
| gptkbp:structure |
contains DNA-binding domain
contains ligand-binding domain |
| gptkbp:target |
gptkb:obeticholic_acid
GW4064 |
| gptkbp:UniProtID |
Q96RI1
|
| gptkbp:bfsParent |
gptkb:retinoid_X_receptor_(RXR)
|
| gptkbp:bfsLayer |
7
|