Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
nuclear receptor |
| gptkbp:alternativeName |
gptkb:NR1I1
calcitriol receptor |
| gptkbp:associatedWith |
hereditary vitamin D resistant rickets
|
| gptkbp:binds |
gptkb:1,25-dihydroxyvitamin_D3
|
| gptkbp:encodedBy |
VDR gene
|
| gptkbp:expressedIn |
gptkb:bone
gptkb:kidney parathyroid gland intestine immune cells |
| gptkbp:formsComplexWith |
gptkb:retinoid_X_receptor_(RXR)
|
| gptkbp:foundIn |
humans
mammals |
| gptkbp:function |
regulates gene expression
mediates effects of vitamin D |
| gptkbp:hasPolymorphism |
gptkb:ApaI
gptkb:BsmI gptkb:TaqI gptkb:FokI |
| gptkbp:HGNC_ID |
gptkb:HGNC:12679
|
| https://www.w3.org/2000/01/rdf-schema#label |
vitamin D receptor (VDR)
|
| gptkbp:involvedIn |
gptkb:metabolic_syndrome
cancer biology autoimmune diseases cardiovascular health skin health inflammatory response insulin secretion cellular signaling pathways bone mineralization hair cycle regulation |
| gptkbp:locatedIn |
cell nucleus
|
| gptkbp:locatedOnChromosome |
chromosome 12q13.11 (human)
|
| gptkbp:memberOf |
nuclear receptor subfamily 1 group I member 1
|
| gptkbp:modulatedBy |
apoptosis
cell differentiation cell proliferation immune response |
| gptkbp:OMIM |
601769
|
| gptkbp:PDB |
gptkb:1DB1
|
| gptkbp:regulates |
calcium homeostasis
phosphate metabolism |
| gptkbp:target |
vitamin D analogs
|
| gptkbp:UniProtID |
P11473
|
| gptkbp:bfsParent |
gptkb:retinoid_X_receptor_(RXR)
|
| gptkbp:bfsLayer |
7
|