peroxisome proliferator-activated receptor (PPAR)
GPTKB entity
Statements (41)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
transcription factor
nuclear receptor protein |
| gptkbp:abbreviation |
PPAR
|
| gptkbp:activatedBy |
ligands
fatty acids eicosanoids |
| gptkbp:affects |
cholesterol metabolism
fatty acid oxidation inflammatory response insulin sensitivity adipogenesis |
| gptkbp:binds |
peroxisome proliferator response elements (PPREs)
|
| gptkbp:discoveredBy |
1990
|
| gptkbp:encodedBy |
PPARG gene
PPARA gene PPARD gene |
| gptkbp:expressedIn |
gptkb:skeletal_muscle
gptkb:kidney heart liver adipose tissue |
| gptkbp:formsHeterodimerWith |
gptkb:retinoid_X_receptor_(RXR)
|
| gptkbp:foundIn |
vertebrates
|
| gptkbp:has_clinical_relevance_in |
gptkb:type_2_diabetes
gptkb:metabolic_syndrome obesity atherosclerosis dyslipidemia |
| https://www.w3.org/2000/01/rdf-schema#label |
peroxisome proliferator-activated receptor (PPAR)
|
| gptkbp:involves |
lipid metabolism
glucose homeostasis inflammation regulation |
| gptkbp:regulates |
gene expression
|
| gptkbp:subspecies |
gptkb:PPAR-gamma
PPAR-alpha PPAR-beta/delta |
| gptkbp:target |
gptkb:thiazolidinediones
fibrate drugs |
| gptkbp:bfsParent |
gptkb:PDK2
gptkb:retinoid_X_receptor_(RXR) |
| gptkbp:bfsLayer |
7
|