peroxisome proliferator-activated receptor (PPAR)

URI: https://gptkb.org/entity/peroxisome_proliferator-activated_receptor_(PPAR)
GPTKB entity
Statements (40)
Predicate Object
gptkbp:instanceOf gptkb:transcription_factor
gptkb:nuclear_receptor_protein
gptkbp:abbreviation PPAR
gptkbp:activatedBy ligands
fatty acids
eicosanoids
gptkbp:affects cholesterol metabolism
fatty acid oxidation
inflammatory response
insulin sensitivity
adipogenesis
gptkbp:binds peroxisome proliferator response elements (PPREs)
gptkbp:discoveredBy 1990
gptkbp:encodedBy PPARG gene
PPARA gene
PPARD gene
gptkbp:expressedIn gptkb:adipose_tissue
gptkb:skeletal_muscle
gptkb:kidney
heart
liver
gptkbp:formsHeterodimerWith gptkb:retinoid_X_receptor_(RXR)
gptkbp:foundIn vertebrates
gptkbp:has_clinical_relevance_in gptkb:type_2_diabetes
gptkb:metabolic_syndrome
obesity
atherosclerosis
dyslipidemia
gptkbp:involves lipid metabolism
glucose homeostasis
inflammation regulation
gptkbp:regulates gene expression
gptkbp:subspecies gptkb:PPAR-gamma
PPAR-alpha
PPAR-beta/delta
gptkbp:target gptkb:thiazolidinediones
fibrate drugs
gptkbp:bfsParent gptkb:PDK2
gptkbp:bfsLayer 7
https://www.w3.org/2000/01/rdf-schema#label peroxisome proliferator-activated receptor (PPAR)