retinoblastoma protein (Rb)
GPTKB entity
Statements (73)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
3
|
| gptkbp:bfsParent |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:healthcare_organization
|
| gptkbp:clinical_trial |
mediated by ubiquitin-proteasome pathway
|
| gptkbp:discovered_by |
gptkb:David_A._Knudson
|
| gptkbp:established |
gptkb:cyclin-dependent_kinases
cell proliferation E2 F activity viral oncoproteins |
| gptkbp:function |
regulates the cell cycle
|
| gptkbp:genetic_diversity |
gptkb:sporadic_retinoblastoma
linked to cancer |
| https://www.w3.org/2000/01/rdf-schema#label |
retinoblastoma protein (Rb)
|
| gptkbp:interacts_with |
E2 F transcription factors
|
| gptkbp:is_aimed_at |
cancer therapies
oncogenic viruses |
| gptkbp:is_associated_with |
cellular senescence
oncogenesis cellular growth control cellular differentiation processes tumor markers other tumor suppressors |
| gptkbp:is_critical_for |
cell cycle progression
cellular function cellular differentiation cellular signaling pathways cellular integrity tumor prevention |
| gptkbp:is_essential_for |
normal retinal development
|
| gptkbp:is_involved_in |
DNA damage response
apoptosis regulation cellular homeostasis cellular metabolism tumor suppression tumorigenesis cellular signaling pathways cell cycle arrest cellular signaling cellular repair mechanisms G1 phase of the cell cycle cellular apoptosis cancer metastasis tumor cell behavior |
| gptkbp:is_linked_to |
gptkb:hereditary_retinoblastoma
gptkb:neuroblastoma chromosomal instability tumor microenvironment retinal degeneration tumor progression tumor suppressor pathways |
| gptkbp:is_part_of |
cell cycle regulation
retinoblastoma signaling pathway |
| gptkbp:is_represented_in |
gptkb:smartphone
gptkb:embryonic_development various tissues various cancers retinal cells cancerous tissues neural tissues neoplastic tissues |
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:location |
gptkb:physicist
|
| gptkbp:metabolism |
regulates activity
|
| gptkbp:promoter |
R B1
|
| gptkbp:regulates |
cellular stress
growth factors cell signaling pathways epigenetic factors external signals phosphorylation state transcription of genes |
| gptkbp:role |
tumor suppressor
|