retinoblastoma protein (Rb)

URI: https://gptkb.org/entity/retinoblastoma_protein_(Rb)
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:pRb
gptkbp:binds gptkb:E2F1
gptkb:HDAC1
LXCXE motif-containing proteins
gptkbp:decommissioned gptkb:HPV_E7_protein
gptkb:SV40_large_T_antigen
gptkb:adenovirus_E1A_protein
viral oncoproteins
gptkbp:discoveredBy gptkb:Weinberg_laboratory
gptkbp:encodedBy gptkb:RB1_gene
gptkbp:firstDescribed 1986
gptkbp:function tumor suppressor
https://www.w3.org/2000/01/rdf-schema#label retinoblastoma protein (Rb)
gptkbp:inhibitedBy gptkb:E2F_transcription_factors
gptkbp:involvedIn G1/S cell cycle checkpoint
gptkbp:locatedIn gptkb:nucleus
gptkbp:locatedOnChromosome 13q14.2
gptkbp:memberOf pocket protein family
gptkbp:molecularWeight ~110 kDa
gptkbp:mutationAssociatedWith gptkb:retinoblastoma
various cancers
gptkbp:orthologIn p107
p130
gptkbp:phosphorylates inactive
cyclin-dependent kinases (CDKs)
gptkbp:postTranslationalModification phosphorylation
ubiquitination
acetylation
gptkbp:regulates cell cycle
gptkbp:requires cellular senescence
cellular differentiation
gptkbp:role DNA damage response
apoptosis regulation
developmental processes
transcriptional repression
chromatin remodeling
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure C-terminal domain
pocket domain
N-terminal domain
gptkbp:target gptkb:cancer
therapeutic research
gptkbp:UniProtID P06400
gptkbp:unphosphorylatedForm active
gptkbp:bfsParent gptkb:G1_checkpoint
gptkbp:bfsLayer 7