|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:NGF
gptkb:beta-NGF
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
peripheral neuropathy
|
|
gptkbp:biologicalProcess
|
neurogenesis
axon growth
neuronal survival
|
|
gptkbp:category
|
growth factor
neurotrophin
|
|
gptkbp:cellularComponent
|
extracellular space
secreted
|
|
gptkbp:discoveredBy
|
gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
|
|
gptkbp:expressedIn
|
brain
salivary gland
immune cells
|
|
gptkbp:fullName
|
gptkb:Nerve_Growth_Factor
|
|
gptkbp:function
|
promotes survival and differentiation of neurons
|
|
gptkbp:gene
|
gptkb:Ngf
|
|
gptkbp:GOID
|
gptkb:GO:0005155
gptkb:GO:0007267
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
rat NGF
|
|
gptkbp:locatedOnChromosome
|
chromosome 1 (rat)
|
|
gptkbp:molecularWeight
|
~26 kDa
|
|
gptkbp:organism
|
gptkb:Rattus_norvegicus
|
|
gptkbp:orthologIn
|
gptkb:mouse_NGF
gptkb:human_NGF
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:neurotrophin_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:1BET
gptkb:1SGF
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:recipient
|
gptkb:TrkA
gptkb:p75NTR
|
|
gptkbp:regulates
|
regulated by cytokines
upregulated by inflammation
|
|
gptkbp:sequence
|
gptkb:protein
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:subunit
|
gptkb:beta-NGF
gptkb:alpha-NGF
gptkb:gamma-NGF
|
|
gptkbp:UniProtID
|
gptkb:P01139
|
|
gptkbp:usedIn
|
neuroscience research
animal models
cell culture experiments
|
|
gptkbp:bfsParent
|
gptkb:Beta-NGF
gptkb:Nerve_Growth_Factor
|
|
gptkbp:bfsLayer
|
7
|