|
gptkbp:instanceOf
|
gptkb:protein
neurotrophin
|
|
gptkbp:alternativeName
|
gptkb:NGF
gptkb:beta-NGF
|
|
gptkbp:category
|
neurobiology
growth factor
signaling molecule
|
|
gptkbp:discoveredBy
|
gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
|
|
gptkbp:discoveredIn
|
1950s
|
|
gptkbp:encodedBy
|
NGF gene
|
|
gptkbp:expressedIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:function
|
regulates development of sympathetic and sensory neurons
promotes growth and survival of neurons
|
|
gptkbp:gene
|
gptkb:NGF
|
|
gptkbp:GO
|
GO:0005169
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Nerve Growth Factor
|
|
gptkbp:involvedIn
|
cell survival
synaptic transmission
neurogenesis
inflammatory response
nociception
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p13.1
|
|
gptkbp:medicalUse
|
investigated for neurodegenerative disorders
|
|
gptkbp:MeSH_ID
|
D009435
|
|
gptkbp:molecularWeight
|
26 kDa
|
|
gptkbp:NobelPrizeYear
|
Rita Levi-Montalcini and Stanley Cohen, Nobel Prize in Physiology or Medicine, 1986
|
|
gptkbp:OMIM
|
162030
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:orthologIn
|
gptkb:mouse_NGF
gptkb:rat_NGF
|
|
gptkbp:PDB
|
gptkb:1BET
|
|
gptkbp:promotion
|
gptkb:synaptic_plasticity
axon growth
|
|
gptkbp:recipient
|
gptkb:TrkA
gptkb:p75NTR
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
neurite outgrowth
|
|
gptkbp:relatedTo
|
gptkb:Alzheimer's_disease
neurodegenerative diseases
pain modulation
|
|
gptkbp:sequence
|
protein-coding
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
gptkb:P01138
|
|
gptkbp:bfsParent
|
gptkb:NGF
|
|
gptkbp:bfsLayer
|
6
|