|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Beta-NGF
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
neurodegenerative diseases
pain perception
|
|
gptkbp:biologicalProcess
|
gptkb:synaptic_plasticity
cell survival
neurite outgrowth
axon guidance
|
|
gptkbp:category
|
growth factor
signaling molecule
neurotrophin
biomarker
|
|
gptkbp:discoveredBy
|
gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
|
|
gptkbp:discoveredIn
|
1950s
|
|
gptkbp:encodedBy
|
NGF gene
|
|
gptkbp:Entrez_Gene_ID
|
4803 (human)
|
|
gptkbp:fullName
|
Nerve growth factor
|
|
gptkbp:function
|
regulates development of sympathetic and sensory neurons
promotes growth and survival of neurons
|
|
gptkbp:gene
|
gptkb:NGF
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ngf
|
|
gptkbp:locatedOnChromosome
|
1p13.1 (human)
|
|
gptkbp:medicalUse
|
investigated for neurodegenerative disease therapy
investigated for pain management
|
|
gptkbp:molecularWeight
|
~26 kDa (homodimer)
|
|
gptkbp:NobelPrizeYear
|
Rita Levi-Montalcini and Stanley Cohen won Nobel Prize in Physiology or Medicine in 1986 for NGF discovery
|
|
gptkbp:OMIM
|
162030
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:orthologIn
|
gptkb:mouse_NGF
gptkb:rat_NGF
chicken NGF
|
|
gptkbp:PDB
|
gptkb:1BET
|
|
gptkbp:recipient
|
gptkb:TrkA
gptkb:p75NTR
|
|
gptkbp:sequence
|
gptkb:protein
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:tissue_specificity
|
brain
peripheral nervous system
immune system
|
|
gptkbp:UniProtID
|
gptkb:P01138
|
|
gptkbp:bfsParent
|
gptkb:mouse_NGF
gptkb:rat_NGF
|
|
gptkbp:bfsLayer
|
8
|