|
gptkbp:instanceOf
|
gptkb:protein
growth factor
|
|
gptkbp:alternativeName
|
gptkb:NGF-beta
gptkb:nerve_growth_factor_beta_chain
|
|
gptkbp:discoveredBy
|
gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
|
|
gptkbp:EC_number
|
3.4.24.68
|
|
gptkbp:encodedBy
|
NGF gene
|
|
gptkbp:expressedIn
|
central nervous system
peripheral nervous system
salivary glands
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
gptkb:Beta_nerve_growth_factor
|
|
gptkbp:function
|
stimulates growth and differentiation of nerve cells
promotes survival of sympathetic and sensory neurons
|
|
gptkbp:GO
|
GO:0005160 (nerve growth factor receptor binding)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Beta-NGF
|
|
gptkbp:involvedIn
|
pain modulation
inflammation
immune response
|
|
gptkbp:locatedOnChromosome
|
1p13.1 (human)
|
|
gptkbp:medicalUse
|
studied for neurodegenerative diseases
studied for peripheral neuropathy
studied for wound healing
|
|
gptkbp:molecularWeight
|
26 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hereditary_sensory_and_autonomic_neuropathy_type_V
gptkb:congenital_insensitivity_to_pain
|
|
gptkbp:OMIM
|
162030
|
|
gptkbp:orthologIn
|
gptkb:mouse_NGF
gptkb:rat_NGF
|
|
gptkbp:partOf
|
gptkb:NGF_protein_complex
|
|
gptkbp:PDB
|
gptkb:1BET
|
|
gptkbp:producedBy
|
macrophages
Schwann cells
fibroblasts
astrocytes
epithelial cells
|
|
gptkbp:recipient
|
gptkb:TrkA
gptkb:p75NTR
|
|
gptkbp:regulates
|
gptkb:synaptic_plasticity
axon growth
neuronal survival
|
|
gptkbp:relatedTo
|
neurotrophin family
|
|
gptkbp:sequence
|
polypeptide
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
gptkb:P01138
|
|
gptkbp:bfsParent
|
gptkb:NGF
|
|
gptkbp:bfsLayer
|
6
|