|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:BDNF
gptkb:NT-3
gptkb:NT-4/5
pain disorders
|
|
gptkbp:biologicalProcess
|
gptkb:neurotrophin_signaling_pathway
cell survival
pain perception
axon guidance
|
|
gptkbp:category
|
growth factor
signaling molecule
secreted protein
|
|
gptkbp:clinicalTrialPhase
|
NGF gene therapy for Alzheimer's disease
|
|
gptkbp:discoveredBy
|
gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
|
|
gptkbp:discoveredIn
|
1950s
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000134259
|
|
gptkbp:expressedIn
|
central nervous system
peripheral nervous system
immune cells
salivary glands
|
|
gptkbp:family
|
neurotrophin family
|
|
gptkbp:fullName
|
gptkb:Nerve_Growth_Factor
|
|
gptkbp:function
|
promotes survival and differentiation of neurons
|
|
gptkbp:gene
|
gptkb:NGF
|
|
gptkbp:GOID
|
GO:0005184
|
|
gptkbp:HGNC_ID
|
gptkb:NGF
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human NGF
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p13.1
|
|
gptkbp:matureFormLength
|
118 amino acids
|
|
gptkbp:medicalUse
|
potential treatment for neurodegenerative diseases
|
|
gptkbp:molecularWeight
|
13 kDa (mature form)
26 kDa (precursor)
|
|
gptkbp:OMIM
|
162030
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_NGF
gptkb:rat_NGF
|
|
gptkbp:PDB
|
gptkb:1BET
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:recipient
|
gptkb:TrkA
gptkb:p75NTR
|
|
gptkbp:RefSeq
|
NP_002497.2
|
|
gptkbp:sequence
|
241 amino acids (precursor)
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:symbol
|
gptkb:NGF
|
|
gptkbp:UniProtID
|
gptkb:P01138
|
|
gptkbp:bfsParent
|
gptkb:mouse_NGF
gptkb:rat_NGF
|
|
gptkbp:bfsLayer
|
8
|