|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:G_protein-coupled_receptors
|
|
gptkbp:activatedState
|
GTP-bound
|
|
gptkbp:alphaSubunitFunction
|
binds and hydrolyzes GTP
|
|
gptkbp:alsoKnownAs
|
guanine nucleotide-binding proteins
|
|
gptkbp:betaGammaComplexFunction
|
modulates effector proteins
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
hydrolysis of GTP to GDP
|
|
gptkbp:discoveredBy
|
gptkb:Martin_Rodbell
gptkb:Alfred_G._Gilman
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:whooping_cough
cholera
endocrine disorders
|
|
gptkbp:encodedBy
|
gptkb:GNA_genes
|
|
gptkbp:foundIn
|
eukaryotic cells
|
|
gptkbp:function
|
molecular switches
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
G proteins
|
|
gptkbp:inactiveState
|
GDP-bound
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
signal transduction
vesicle trafficking
cell growth
immune response
visual signaling
cytoskeletal organization
hormone signaling
metabolic regulation
neurotransmitter signaling
olfactory signaling
|
|
gptkbp:location
|
inner surface of plasma membrane
|
|
gptkbp:NobelPrizeYear
|
gptkb:1994_Nobel_Prize_in_Physiology_or_Medicine
|
|
gptkbp:regulates
|
gptkb:phospholipase_C
gptkb:regulators_of_G_protein_signaling_(RGS_proteins)
ion channels
adenylyl cyclase
phosphodiesterases
|
|
gptkbp:relatedTo
|
gptkb:G_protein-coupled_receptors
cell signaling
second messenger systems
|
|
gptkbp:structure
|
heterotrimeric complex
|
|
gptkbp:subunit
|
alpha subunit
beta subunit
gamma subunit
|
|
gptkbp:type
|
small GTPases
heterotrimeric G proteins
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptors
|
|
gptkbp:bfsLayer
|
5
|