|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
hypertension
|
|
gptkbp:biologicalProcess
|
phospholipase activity
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
molecular cloning
|
|
gptkbp:encodes
|
phospholipase C beta-3 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000138061
5331
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1992
|
|
gptkbp:fullName
|
phospholipase C beta 3
|
|
gptkbp:function
|
generates second messengers IP3 and DAG
hydrolyzes phosphatidylinositol 4,5-bisphosphate
|
|
gptkbp:HGNC_ID
|
9066
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLCB3
|
|
gptkbp:involvedIn
|
signal transduction
calcium signaling pathway
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
11q13.1
|
|
gptkbp:OMIM
|
602142
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Plcb3
|
|
gptkbp:PDB
|
2FJU
|
|
gptkbp:proteinFamily
|
gptkb:phospholipase_C_family
|
|
gptkbp:regulates
|
activated by G-protein alpha subunits
regulated by calcium ions
|
|
gptkbp:UniProtID
|
Q01970
|
|
gptkbp:bfsParent
|
gptkb:phospholipase_C
|
|
gptkbp:bfsLayer
|
6
|