|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
PLC-1
PLCgamma1
phospholipase C-gamma-1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
angiogenesis
|
|
gptkbp:discoveredBy
|
1989
|
|
gptkbp:domain
|
gptkb:PH_domain
gptkb:EF-hand_domain
C2 domain
SH2 domain
SH3 domain
|
|
gptkbp:encodes
|
phospholipase C gamma 1 protein
|
|
gptkbp:Entrez_Gene_ID
|
5335
ENSG00000197943
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
phospholipase C gamma 1
|
|
gptkbp:function
|
generates second messengers IP3 and DAG
hydrolyzes phosphatidylinositol 4,5-bisphosphate
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
9065
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLCG1
|
|
gptkbp:interactsWith
|
gptkb:EGFR
gptkb:FGFR1
gptkb:SRC
gptkb:GRB2
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
signal transduction
cell migration
|
|
gptkbp:locatedOnChromosome
|
20
|
|
gptkbp:location
|
20q12-q13.1
|
|
gptkbp:molecularWeight
|
~148 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
immune disorders
|
|
gptkbp:OMIM
|
172420
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Plcg1
|
|
gptkbp:PDB
|
4FBN
|
|
gptkbp:phosphorylates
|
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:regulates
|
calcium signaling
PKC activation
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
P19174
|
|
gptkbp:bfsParent
|
gptkb:phospholipase_C
|
|
gptkbp:bfsLayer
|
6
|