|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
autoimmune disease
immune response
|
|
gptkbp:biologicalProcess
|
phospholipase activity
calcium ion binding
SH2 domain binding
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
Kazuo Suzuki et al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:domain
|
gptkb:PH_domain
gptkb:EF-hand_domain
C2 domain
SH2 domain
SH3 domain
catalytic domain
|
|
gptkbp:encodes
|
phospholipase C gamma 2
|
|
gptkbp:Entrez_Gene_ID
|
5336
ENSG00000197943
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:function
|
signal transduction
hydrolyzes phosphatidylinositol 4,5-bisphosphate
|
|
gptkbp:HGNC_ID
|
9066
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLCG2
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:BLNK
gptkb:VAV1
gptkb:LAT
gptkb:GRB2
gptkb:BTK
gptkb:LYN
SYK
|
|
gptkbp:length
|
1265
|
|
gptkbp:locatedOnChromosome
|
16q23.3
|
|
gptkbp:molecularWeight
|
145 kDa
|
|
gptkbp:mutationAssociatedWith
|
APLAID syndrome
PLAID syndrome
|
|
gptkbp:OMIM
|
600220
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Plcg2
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:B_cell_receptor_signaling_pathway
Fc-epsilon receptor signaling pathway
|
|
gptkbp:proteinFamily
|
gptkb:phospholipase_C_family
|
|
gptkbp:regulates
|
activated by tyrosine phosphorylation
|
|
gptkbp:UniProtID
|
P16885
|
|
gptkbp:bfsParent
|
gptkb:phospholipase_C
|
|
gptkbp:bfsLayer
|
6
|