phosphatidylinositol 3-kinase (PI3K)

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:PI3K
gptkbp:catalyzes phosphorylation of phosphatidylinositol lipids
gptkbp:discoveredBy gptkb:Lewis_Cantley
gptkbp:EC_number 2.7.1.153
gptkbp:firstDescribed 1988
gptkbp:foundIn eukaryotic cells
gptkbp:gene gptkb:PIK3CA
gptkb:PIK3CB
gptkb:PIK3CD
gptkb:PIK3CG
gptkbp:hasIsoform gptkb:PI3K_beta
gptkb:PI3K_gamma
gptkb:PI3K_delta
gptkb:PI3K_alpha
gptkbp:hasType gptkb:Class_III_PI3K
gptkb:Class_II_PI3K
gptkb:Class_I_PI3K
https://www.w3.org/2000/01/rdf-schema#label phosphatidylinositol 3-kinase (PI3K)
gptkbp:inhibitedBy gptkb:LY294002
gptkb:wortmannin
gptkbp:involvedIn gptkb:PI3K/AKT_signaling_pathway
cell proliferation
cell survival
metabolism
cancer progression
cell growth regulation
gptkbp:mutationAssociatedWith gptkb:cancer
immunodeficiency
gptkbp:product gptkb:phosphatidylinositol_3,4,5-trisphosphate
gptkb:phosphatidylinositol_3,4-bisphosphate
phosphatidylinositol 3-phosphate
gptkbp:regulates gptkb:AKT
gptkb:mTOR
apoptosis
angiogenesis
cell migration
glucose metabolism
immune response
cell cycle
gptkbp:relatedTo phosphoinositide 3-kinase pathway
gptkbp:substrate phosphatidylinositol
phosphatidylinositol 4,5-bisphosphate
phosphatidylinositol 4-phosphate
gptkbp:subunit p110 catalytic subunit
p85 regulatory subunit
gptkbp:target PI3K inhibitors
gptkbp:bfsParent gptkb:PI3K/AKT_signaling_pathway
gptkbp:bfsLayer 6