|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:Gβγ_subunits
gptkb:G_protein-coupled_receptors_(GPCRs)
|
|
gptkbp:affiliatedWith
|
gptkb:class_I_PI3K
|
|
gptkbp:alternativeName
|
gptkb:PIK3CG_protein
gptkb:p110_gamma
gptkb:phosphoinositide_3-kinase_gamma
|
|
gptkbp:associatedWith
|
gptkb:cancer
cardiovascular diseases
inflammatory diseases
|
|
gptkbp:biologicalProcess
|
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
|
|
gptkbp:catalyzes
|
phosphorylation of phosphatidylinositol (4,5)-bisphosphate
|
|
gptkbp:discoveredBy
|
gptkb:Bart_Vanhaesebroeck
|
|
gptkbp:EC_number
|
2.7.1.153
|
|
gptkbp:encodedBy
|
gptkb:PIK3CG_gene
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
heart
endothelial cells
|
|
gptkbp:formsComplexWith
|
gptkb:p101
gptkb:p84
|
|
gptkbp:hasCatalyticSubunit
|
gptkb:p110γ
|
|
gptkbp:hasRegulatorySubunit
|
gptkb:p101
gptkb:p84
|
|
gptkbp:hasRole
|
innate immunity
adaptive immunity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3K gamma
|
|
gptkbp:inhibitedBy
|
gptkb:IPI-549
AS-605240
CZC24832
|
|
gptkbp:involvedIn
|
cell signaling
inflammation
chemotaxis
immune cell migration
|
|
gptkbp:locatedOnChromosome
|
gptkb:7q22.3_(human)
|
|
gptkbp:molecularWeight
|
126 kDa (p110γ subunit)
|
|
gptkbp:orthologIn
|
Mus musculus (mouse)
Rattus norvegicus (rat)
Homo sapiens (human)
|
|
gptkbp:produces
|
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate_(PIP3)
|
|
gptkbp:regulates
|
gptkb:AKT_signaling_pathway
cell proliferation
cell survival
cell migration
superoxide production in neutrophils
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P48736
|
|
gptkbp:bfsParent
|
gptkb:PIK3CG
gptkb:class_I_PI3K
|
|
gptkbp:bfsLayer
|
5
|