Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:PIK3CA
gptkb:phosphoinositide_3-kinase_alpha |
| gptkbp:biologicalProcess |
cell proliferation
cell survival metabolism angiogenesis cell growth kinase activity |
| gptkbp:cellularComponent |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:discoveredBy |
gptkb:Lewis_Cantley
|
| gptkbp:discoveredIn |
1988
|
| gptkbp:EC_number |
2.7.1.153
|
| gptkbp:encodedBy |
gptkb:PIK3CA_gene
|
| gptkbp:function |
catalyzes phosphorylation of phosphatidylinositol-4,5-bisphosphate
involved in PI3K/AKT signaling pathway |
| https://www.w3.org/2000/01/rdf-schema#label |
PI3K alpha
|
| gptkbp:locatedOnChromosome |
3q26.32
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
gptkb:endometrial_cancer colorectal cancer |
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:structure |
heterodimer
|
| gptkbp:subunit |
gptkb:p110α_catalytic_subunit
p85 regulatory subunit |
| gptkbp:target |
gptkb:alpelisib
PI3K inhibitors |
| gptkbp:UniProtID |
gptkb:P42336
|
| gptkbp:bfsParent |
gptkb:class_I_PI3K
|
| gptkbp:bfsLayer |
5
|