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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:PIK3CA
gptkb:phosphoinositide_3-kinase_alpha
|
|
gptkbp:biologicalProcess
|
cell proliferation
cell survival
metabolism
angiogenesis
cell growth
kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Lewis_Cantley
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:EC_number
|
2.7.1.153
|
|
gptkbp:encodedBy
|
gptkb:PIK3CA_gene
|
|
gptkbp:function
|
catalyzes phosphorylation of phosphatidylinositol-4,5-bisphosphate
involved in PI3K/AKT signaling pathway
|
|
gptkbp:locatedOnChromosome
|
3q26.32
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:endometrial_cancer
colorectal cancer
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
heterodimer
|
|
gptkbp:subunit
|
gptkb:p110α_catalytic_subunit
p85 regulatory subunit
|
|
gptkbp:target
|
gptkb:alpelisib
PI3K inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P42336
|
|
gptkbp:bfsParent
|
gptkb:phosphatidylinositol_4,5-bisphosphate_3-kinase_catalytic_subunit_alpha
gptkb:taselisib
gptkb:RLY-2608
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3K alpha
|