Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
SKP1-CUL1-F-box protein complex (SKP2 type)
|
| gptkbp:component |
gptkb:RBX1
gptkb:SKP2 CUL1 SKP1 |
| gptkbp:discoveredIn |
late 1990s
|
| gptkbp:E3_ligase_family |
SCF complex
|
| gptkbp:F-box_protein |
gptkb:SKP2
|
| gptkbp:function |
E3 ubiquitin ligase
ubiquitination of p27Kip1 |
| https://www.w3.org/2000/01/rdf-schema#label |
SCF(SKP2) complex
|
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:regulates |
cell cycle progression
|
| gptkbp:relatedTo |
gptkb:cancer
cell proliferation proteasomal degradation |
| gptkbp:target |
gptkb:p21Cip1
gptkb:p27Kip1 gptkb:p57Kip2 |
| gptkbp:bfsParent |
gptkb:p27
|
| gptkbp:bfsLayer |
6
|