|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CCNE
gptkb:Cyclin_E
gptkb:Cyclin-E
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
cell cycle
DNA replication initiation
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:degradedBy
|
gptkb:SCF(FBW7)_complex
|
|
gptkbp:encodes
|
gptkb:Cyclin_E1_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105173
898
|
|
gptkbp:expressedIn
|
embryonic tissues
proliferating cells
tumor tissues
|
|
gptkbp:fullName
|
gptkb:Cyclin_E1
|
|
gptkbp:function
|
regulation of cell cycle
G1/S transition of mitotic cell cycle
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO:molecularFunction
|
cyclin-dependent protein serine/threonine kinase regulator activity
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:1588
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CCNE1
|
|
gptkbp:inhibitedBy
|
CDK inhibitors
|
|
gptkbp:interactsWith
|
gptkb:p21Cip1
gptkb:CDK2
gptkb:p27Kip1
|
|
gptkbp:length
|
410 amino acids
|
|
gptkbp:locatedOnChromosome
|
19q12
|
|
gptkbp:molecularWeight
|
47 kDa
|
|
gptkbp:mutationAssociatedWith
|
genomic instability
|
|
gptkbp:OMIM
|
123837
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ccne1
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
|
|
gptkbp:PDB
|
gptkb:1W98
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:proteinFamily
|
cyclin family
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:E2F_transcription_factors
DNA replication
centrosome duplication
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
P24864
|
|
gptkbp:bfsParent
|
gptkb:EGR1
|
|
gptkbp:bfsLayer
|
6
|