|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CDK4I
gptkb:INK4A
gptkb:MELANOMA_MULTIPLE_MOLE_SYNDROME_1
gptkb:MTS1
|
|
gptkbp:alsoKnownAs
|
gptkb:CDKN2A
gptkb:cyclin-dependent_kinase_inhibitor_2A
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:CDKN1A
gptkb:CDKN2B
gptkb:CDKN2C
aging
senescence
|
|
gptkbp:discoveredBy
|
gptkb:David_Beach
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:p16INK4a
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000147889
1029
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
tumor suppressor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasBiomarker
|
gptkb:HPV-associated_cancers
cellular senescence
|
|
gptkbp:HGNC_ID
|
1787
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p16
|
|
gptkbp:inhibitedBy
|
gptkb:CDK4
gptkb:CDK6
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9
gptkb:9p21
|
|
gptkbp:methylationAssociatedWith
|
cancer progression
gene silencing
|
|
gptkbp:molecularWeight
|
16 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:glioblastoma
melanoma
pancreatic cancer
bladder cancer
head and neck cancer
|
|
gptkbp:OMIM
|
600160
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn2a
|
|
gptkbp:prevention
|
phosphorylation of RB protein
|
|
gptkbp:product
|
gptkb:p14ARF
gptkb:p16INK4a
|
|
gptkbp:regulates
|
gptkb:p53
gptkb:E2F
cell cycle
G1 phase of cell cycle
|
|
gptkbp:relatedTo
|
gptkb:familial_atypical_multiple_mole_melanoma_syndrome
|
|
gptkbp:UniProtID
|
gptkb:P42771
|
|
gptkbp:bfsParent
|
gptkb:head_and_neck_squamous_cell_carcinoma
|
|
gptkbp:bfsLayer
|
6
|