|
gptkbp:instanceOf
|
UniProt accession number
|
|
gptkbp:alternativeName
|
Cyclin-dependent kinase inhibitor 2A
Multiple tumor suppressor 1
p16-INK4a
|
|
gptkbp:biologicalProcess
|
Cyclin-dependent protein serine/threonine kinase inhibitor activity
Protein binding
|
|
gptkbp:database
|
gptkb:UniProt
HGNC:1787
Ensembl:ENSG00000147889
NCBI Gene:1029
OMIM:600160
|
|
gptkbp:discoveredBy
|
gptkb:David_Beach
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:expressedIn
|
Widely expressed in human tissues
|
|
gptkbp:function
|
Tumor suppressor
Inhibits CDK4 and CDK6
|
|
gptkbp:gene
|
gptkb:CDKN2A
|
|
gptkbp:hasIsoform
|
p14ARF (alternative reading frame)
p16-INK4a
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P42771
|
|
gptkbp:involvedIn
|
Cell cycle regulation
Cellular senescence
|
|
gptkbp:length
|
156 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:9p21
9
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Melanoma
gptkb:Glioblastoma
gptkb:Pancreatic_cancer
gptkb:Bladder_cancer
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mouse Cdkn2a
Rat Cdkn2a
|
|
gptkbp:pathway
|
p53 signaling pathway
Cell cycle, G1/S transition
|
|
gptkbp:postTranslationalModification
|
Phosphorylation
Ubiquitination
|
|
gptkbp:protein_existence
|
Evidence at protein level
|
|
gptkbp:proteinFamily
|
gptkb:INK4_family
|
|
gptkbp:refersTo
|
Human protein CDKN2A
|
|
gptkbp:sequenceStatus
|
Reviewed
|
|
gptkbp:significance
|
Biomarker for cancer risk
Target for cancer therapy
|
|
gptkbp:structure
|
Contains 4 ankyrin repeats
|
|
gptkbp:subcellularLocation
|
gptkb:Nucleus
gptkb:Cytoplasm
|
|
gptkbp:bfsParent
|
gptkb:CDKN2A
|
|
gptkbp:bfsLayer
|
6
|