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gptkbp:instanceOf
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gptkb:UniProt_accession_number
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gptkbp:alternativeName
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Cyclin-dependent kinase inhibitor 2A
Multiple tumor suppressor 1
p16-INK4a
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gptkbp:biologicalProcess
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Cyclin-dependent protein serine/threonine kinase inhibitor activity
Protein binding
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gptkbp:database
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gptkb:UniProt
HGNC:1787
Ensembl:ENSG00000147889
NCBI Gene:1029
OMIM:600160
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gptkbp:discoveredBy
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gptkb:David_Beach
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gptkbp:discoveredIn
|
1993
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gptkbp:expressedIn
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Widely expressed in human tissues
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gptkbp:function
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Tumor suppressor
Inhibits CDK4 and CDK6
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gptkbp:gene
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gptkb:CDKN2A
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gptkbp:hasIsoform
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p14ARF (alternative reading frame)
p16-INK4a
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gptkbp:involvedIn
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Cell cycle regulation
Cellular senescence
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gptkbp:length
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156 amino acids
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gptkbp:locatedOnChromosome
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gptkb:9p21
9
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gptkbp:mutationAssociatedWith
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gptkb:Melanoma
gptkb:Glioblastoma
gptkb:Pancreatic_cancer
gptkb:Bladder_cancer
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
|
Mouse Cdkn2a
Rat Cdkn2a
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gptkbp:pathway
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p53 signaling pathway
Cell cycle, G1/S transition
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gptkbp:postTranslationalModification
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Phosphorylation
Ubiquitination
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gptkbp:protein_existence
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Evidence at protein level
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gptkbp:proteinFamily
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gptkb:INK4_family
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gptkbp:refersTo
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Human protein CDKN2A
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gptkbp:sequenceStatus
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Reviewed
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gptkbp:significance
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Biomarker for cancer risk
Target for cancer therapy
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gptkbp:structure
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Contains 4 ankyrin repeats
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gptkbp:subcellularLocation
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gptkb:Nucleus
gptkb:Cytoplasm
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gptkbp:bfsParent
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gptkb:p16
gptkb:CDKN2A
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gptkbp:bfsLayer
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7
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https://www.w3.org/2000/01/rdf-schema#label
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P42771
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