linezolid

GPTKB entity

Statements (30)
Predicate Object
gptkbp:instanceOf gptkb:oxazolidinone
gptkb:antibiotic
gptkbp:approvalYear 2000
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode J01XX08
gptkbp:brand gptkb:Zyvox
gptkbp:CASNumber 165800-03-3
gptkbp:contraindication concurrent use with monoamine oxidase inhibitors (MAOIs)
gptkbp:discoveredBy gptkb:Pharmacia_&_Upjohn
gptkbp:eliminationHalfLife 5-7 hours
gptkbp:excretion urine
gptkbp:hasMolecularFormula C16H20FN3O4
https://www.w3.org/2000/01/rdf-schema#label linezolid
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit
gptkbp:metabolism liver
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 31%
gptkbp:routeOfAdministration oral
intravenous
gptkbp:sideEffect gptkb:anemia
gptkb:serotonin_syndrome
peripheral neuropathy
thrombocytopenia
lactic acidosis
gptkbp:usedFor treatment of vancomycin-resistant Enterococcus (VRE)
treatment of methicillin-resistant Staphylococcus aureus (MRSA)
treatment of infections caused by Gram-positive bacteria
gptkbp:bfsParent gptkb:Zyvox
gptkbp:bfsLayer 5