|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:drug
|
|
gptkbp:administeredBy
|
benserazide
carbidopa
|
|
gptkbp:approvedForMedicalUseIn
|
1967
|
|
gptkbp:ATCCode
|
N04BA01
|
|
gptkbp:bioavailability
|
30%
|
|
gptkbp:CASNumber
|
59-92-7
|
|
gptkbp:category
|
antiparkinsonian agent
dopaminergic agent
|
|
gptkbp:chemicalFormula
|
C9H11NO4
|
|
gptkbp:contraindication
|
narrow-angle glaucoma
|
|
gptkbp:developedBy
|
gptkb:Arvid_Carlsson
|
|
gptkbp:discoveredBy
|
gptkb:Markus_Guggenheim
|
|
gptkbp:discoveredIn
|
1911
|
|
gptkbp:eliminationHalfLife
|
1.5 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:firstSynthesized
|
gptkb:Casimir_Funk
|
|
gptkbp:foundIn
|
gptkb:Mucuna_pruriens
gptkb:broad_beans
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
levodopa
|
|
gptkbp:interactsWith
|
gptkb:monoamine_oxidase_inhibitors
vitamin B6
antipsychotics
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
converted to dopamine in the brain
|
|
gptkbp:meltingPoint
|
275 °C
|
|
gptkbp:metabolism
|
aromatic L-amino acid decarboxylase
catechol-O-methyltransferase
|
|
gptkbp:molecularWeight
|
197.19 g/mol
|
|
gptkbp:predecessor
|
dopamine
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
less than 10%
|
|
gptkbp:PubChem_CID
|
6047
|
|
gptkbp:riskFactor
|
compulsive behaviors
motor fluctuations
on-off phenomenon
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
hypotension
dyskinesia
hallucinations
|
|
gptkbp:synonym
|
gptkb:L-3,4-dihydroxyphenylalanine
gptkb:L-DOPA
|
|
gptkbp:UNII
|
46627O600J
|
|
gptkbp:usedFor
|
gptkb:Parkinson's_disease
dopamine-responsive dystonia
|
|
gptkbp:bfsParent
|
gptkb:Parkinson's_disease
|
|
gptkbp:bfsLayer
|
5
|